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The Emperor of All Maladies: A Biography of Cancer, by Siddhartha Mukherjee
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A magnificent, beautifully written epic "biography" of cancer---in the tradition of Andrew Solomon's The Noonday Demon, this is a brilliant exploration of the past, present, and future of a complex disease that defines us and our time.
- Sales Rank: #1275730 in Books
- Published on: 2010-11-17
- Formats: Audiobook, CD, Unabridged
- Original language: English
- Number of items: 16
- Dimensions: 5.30" h x 1.60" w x 6.40" l, .89 pounds
- Running time: 20 Hours
- Binding: Audio CD
Amazon.com Review
Amazon Best Books of the Month, November 2010: "In 2010, about six hundred thousand Americans, and more than 7 million humans around the world, will die of cancer." With this sobering statistic, physician and researcher Siddhartha Mukherjee begins his comprehensive and eloquent "biography" of one of the most virulent diseases of our time. An exhaustive account of cancer's origins, The Emperor of All Maladies illustrates how modern treatments--multi-pronged chemotherapy, radiation, and surgery, as well as preventative care--came into existence thanks to a century's worth of research, trials, and small, essential breakthroughs around the globe. While The Emperor of All Maladies is rich with the science and history behind the fight against cancer, it is also a meditation on illness, medical ethics, and the complex, intertwining lives of doctors and patients. Mukherjee's profound compassion--for cancer patients, their families, as well as the oncologists who, all too often, can offer little hope--makes this book a very human history of an elusive and complicated disease. --Lynette Mong
From Publishers Weekly
Mukherjee's magisterial history of cancer research is poorly served by Stephen Hoye's impersonal, tone-deaf narration. Mukherjee is a practicing oncologist, and his is a deeply personal account, replete with stories of his own patients and practice, that begs for an intimate reading. But Hoye is pedantic, dry, stentorian-everything that this book isn't-and his newscaster's delivery cannot convey the author's compassion for his patients or the suspense and thrill of scientific discovery that the book so brilliantly describes. A Scribner hardcover. (Nov.)
(c) Copyright PWxyz, LLC. All rights reserved.
From Booklist
*Starred Review* Apparently researching, treating, and teaching about cancer isn’t enough of a challenge for Columbia University cancer specialist Mukherjee. He was also moved to write a biography of a disease whose name, for millennia, could not be uttered. The eminently readable result is a weighty tale of an enigma that has remained outside the grasp of both the people who endeavored to know it and those who would prefer never to have become acquainted with it. An unauthorized biography told through the voices of people who have lived, toiled, and, yes, died under cancer’s inexorable watch. Mukherjee recounts cancer’s first known literary reference—hence its birth, so to speak—in the teachings of the Egyptian physician Imhotep in the twenty-fifth century BCE, in which it is clear that Imhotep possessed no tools with which to treat what appears to be breast cancer. His cryptic note under “Therapy:” “There is none.” Throughout cancer’s subsequent years, many more physicians and scientists with names both familiar and obscure attempted and occasionally succeeded in deciphering or unlocking keys to many of the disease’s mysteries. Alas, this is not a posthumous biography, but it is nonetheless a surprisingly accessible and encouraging narrative. --Donna Chavez
Most helpful customer reviews
26 of 27 people found the following review helpful.
read it after your treatment
By Aaron McLoughlin
Last April I was diagnosed with acute leukaemia. After a stem cell transplant I am coming up for a year.
When you are told you have cancer you are bewildered. You are also very angry. I asked myself was there something I had done in my past that was going to deprive me seeing my two sons grow up into happy young men and dads. The first two weeks go by in a weird nightmare. Day 17 your hair falls out. Your peeing orange from the chemo drugs, which have put me off lucozade for life. You double check all your insurances are up to date and update a well to make sure my wife does not have any hassles with the tax authorities. At the age of 44 you are very angry. You realise you are likely going to die. You are angry because you have no idea what is doing it. What you planned for when you were older is all meaningless. But, thanks to certain stubbornness and amazing treatment and care, and a generous sift of life from a German donor of life giving stem cells, I am alive.
This book helps explain many of the questions I had. It does it in a way that makes sense if you don't have a degree in science. What was until recently a death sentence is no longer the case. The battle against cancer was waged by intrepid individuals, and this book explains the war so far. It outlines the causes of cancer, whether it is a virus, bacteria, induced by smoking or chemicals, or just our own body playing up and turning on itself. It explains how our own understanding is still basic but advancing year by year, and treatments, if not cures, are being found for many, although not all cancers.
I learned that was once a death sentence is not the case today. I am looking forward to see my sons become men. This book gave me clarity, it gave me hope.
4 of 4 people found the following review helpful.
An insider's view of cancer
By Ionut Trestian
I only read this book because Ken Burns produced a documentary on it that is coming out in the Spring of 2015. I really love Ken Burns documentaries, hence the interest. Across the book, there is only one common character, cancer. Although cancer is not a single disease but a collection of several diseases characterized by uncontrolled growth and spread of cells in the body, the book portrays cancer as a great villain, lurking in the shadows, ready to strike at any time. What makes this story different and far from dry is the way S. Mukherjee tells it: "the story of leukemia - the story of cancer - isn't the story of doctors who struggle and survive, moving from one institution to another. It is the story of patients who struggle and survive, moving from one embankment of illness to another. Resilience, inventiveness, and survivorship — qualities often ascribed to great physicians — are reflected qualities, emanating first from those who struggle with illness and only then mirrored by those who treat them. If the history of medicine is told through the stories of doctors, it is because their contributions stand in place of the more substantive heroism of their patients."
Across the book, we are also introduced to ways of fighting or stalling the advance of cancer: radical surgery and radical mastectomy, X-rays, cytotoxics, monoclonal antibodies, tyrosine kinase inhibitors and S. Mukherjee explains really well how all of the above function (or don't function in some cases). One of the strengths of the book is that it gives a behind the scenes look at how certain drugs or procedures came to be (Druker's struggles with developing imatinib) or how other procedures were proven to be too radical and changed such as Halsted's radical mastectomy.
The fight to find a cure for cancer has triggered enormous social forces in the 20th century and in the book we are introduced to some of the main characters: Sidney Farber and the Jimmy Fund, Mary Lasker and the American Cancer Society both determined to enact policy changes that will get more resources allocated to the war against cancer. These are just a few figures in this war, but there were other forces as well that fought for cigarette labeling for example, or more personal struggles related to compassionate drug use.
S. Mukherjee ends the book on a more positive note. All throughout the book we get the impression that primitive forces are battling a very complex disease, using disfiguring surgery or drugs that oftentimes end up causing cancer themselves. The final few chapters are not so gloomy, he takes a molecular biologist's view of the disease and explains our current understanding of the processes and pathways involved and you do get the impression that by 2050 we will be able to target the specific pathways and mutations that make up a particular form of cancer.
3 of 3 people found the following review helpful.
One of the best written research books ever.
By A Bucket of Corn
Review of Book and Ken Burns Series:
One of the best books and also now one of the best Documentary's out there. This is a 3 episode, three disc, exploration and history of one of the greatest mass murderers of all time, CANCER. This documentary is a thoughtful, moving, emotional journey into everything about cancer and what all the doctors, nurses, researchers and victims have gone through. Possibly one of the best, if not the best research examples ever done in written form, and now film form. I have read the book also which I highly recommend and now I highly recommended the 3 Disc Documentary that Ken Burns has created. I have never been so glued, moved, brought to tears as I have by this documentary. Not only does this book and documentary explore the vast history of this horror, but it also puts a face on this monster. It showcases the pain and suffering of those who are ravaged by this beast. It gives an example of not just a word but a living, breathing human being.
Siddhartha Mukherjee is one of the finest human beings to ever grace book form, his book brought to life this horrible reality. He not only brought a face to the monster, but he allowed you to understand the history, and massive exploration for treatment and hopefully one day a cure. In a sense both Siddhartha Mukherjee and Ken Burns has given a voice to this darkness that slowly is causing thousands to die, suffer, or go through.
Not only does this book and documentary explore the vast history of this horror, but it also puts a face on this monster. It showcases the pain and suffering of those who are ravaged by this beast. It gives an example of not just a word but a living, breathing human being.
Siddhartha Mukherjee is one of the finest human beings to ever grace book form, his book brought to life this horrible reality. He not only brought a face to the monster, but he allowed you to understand the history, and massive exploration for treatment and hopefully one day a cure. In a sense both Siddhartha Mukherjee and Ken Burns has given a voice to this darkness that slowly is causing thousands to die, suffer, or go through.
Cancer sadly runs in my family. My sister died of Spinal Cancer. One Aunt died of colon cancer. One Aunt died of Pancreatic Cancer. One Aunt Lung and Brain Cancer. One Uncle Brain Cancer. One Uncle Lung and Brain Cancer. One Uncle Esophagus Cancer. One Uncle Lung Cancer. My Great Grandfather Prostate Cancer. My Dad is a survivor of Prostate Cancer. So I have seen it, experienced its wrath. See the brutality of this beast. I feel the book and Ken Burns Documentary is a prime example of how to look at this Emperor of All Maladies.
A perfect book. A perfect film. Both should be owned, read and watched, taught and expressed to others. Wonderful examples of research both in written form and visual form. Perfection.
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